Inpatient End of Life Care (Selby, 10/9/24)

A recording of this presentation on Inpatient End of Life Care is available HERE.

***

We are so lucky in the hospital to have a talented and knowledgeable hospice liaison, Kristi Selby RN, who very much guides us through the process of transitioning patients onto hospice in the hospital. Most of those patients then discharge to home or the community, but occasionally we get to be witness to death of patient in the hospital. I am personally grateful for Kristi's attentive care of a patient with shared this past week.

I am also grateful to her for an excellent presentation she gave this week outlining the basics of hospice definitions, eligibility, services, and philosophy. Please watch the above link for the whole presentation. If you just want my notes, here they are:

Hospice is a level of care, not a place. Hospice offers expert medical care, pain management, emotional and spiritual support that is tailored to each patient (not to the disease). It includes facility support, bereavement for up to 18 months, and a focus on caring, not curing. It takes into account important aspects like anticipatory grief.

Just like many people these days have birth plans, hospice can help people have the death they want -- a death plan, of sorts. 

In order to be eligible for hospice, you need to have:

• terminal illness
• <6 months prognosis
• no curative treatment desired

While sometimes the condition of a "terminal illness" is obvious, but there are possible factors that can support eligibility for diagnoses that are less routine. These include: weight loss, a decrease in fluid/food intake, recurrent infections, increasing difficulty in attending to ADLs, frequent hospitalizations and/or ED visits, frequent falls with increasing weakness, and rapid progression of disease.

Some quantitative measures (e.g. Albumin <2.5 or EF <20%) can also help make patients eligible for hospice care. 

Additional information that may indicate hospice eligibility includes a change in function, a change in nutritional status, a change in weight, and a change in alertness. Don't forget to document these in your outpatient charts. AND, when in doubt, ask a hospice liaison for help!

Common barriers to entry into hospice include: 

• cultural/death taboo
• many people are unaware of hospice and hospice services
• family or providers don't want to take away hope
• there is a misunderstanding of what hospice is (it's not just give me morphine and kill me)
• death is really hard to talk about!

Hospice levels of care:

• Routine (multidisciplinary team with many visits/week in the home, SNF, etc)
• Continuous care (8 hours shifts, generally by RN)
• Respite care (short term, up to 5 days at a SNF for caregivers)
• General inpatient (GIP), in which a patient who is not stable to receive routine hospice care at home and/or needs up titration of medications can receive that level of care in the hospital

Routine hospice care gets reimbursed about $300/day; in contrast GIP costs Medicare about $2000/day so it must be justified on a daily basis. Issues that can justify GIP hospitalization include pain control, SOB, agitation, nausea/vomiting, wound care or any "skilled' needs

When a GIP patient is in the hospital, we focus on symptom management, which can be a shift for many hospital staff. Hospital care looks different for patients who are dying compared to those who are not dying. This can lead to nurse discomfort. It's important to talk about. In addition, more meds than we are generally accustomed to is better for comfort. We use benzos and opiates together in hospice care for comfort (the exact opposite of what we do for non-hospice patients). 

Finally, Kristi spent some time talking about how every person's situation is unique, every culture is distinct, and in hospice care we are really looking to provide the type of death the patient and their family desire. This may look very different than the type of death WE desire. That difference is okay, but we need to acknowledge it and be sure not to let our medical assumptions get in the way of what patients want. 

The Dobbs Crisis: A Family Medicine Response (Pfeifer, 10/2/24)

 A recording of this presentation is available HERE. 

A written summary will be forthcoming.  

Empiric Antibiotics and SSRRH Antibiogram (Patel, 9/25/24)

 Many thanks to Omi Patel, PharmD and head of our SSRRH pharmacy for an excellent and important talk on Empiric Antibiotics and the SSRRH Antibiogram. A recording of her presentation is available HERE. 

My notes:

Empiric antibiotics should be chosen based on many different factors:

• patient characteristics (age, comorbidities, recent hospitalization, etc)
• site of infection
• pharmacokinetics
• evidence-based guidelines (e.g. IDSA, John's Hopkins, Sanford guide)
• facility specific guidelines (CPMC, UCSF)
• clinical pathways (most recent possible)
• local antibiogram (which is what this talk focused on)

At SSRRH, there is a system-wide order set that offers empiric antibiotic options based on site of infection. It is available under order sets. Do NOTE these are not specific to SSRRH, and our local antibiogram should be consulted if using these order sets.

As noted above, the hospital specific antibiogram is essential to good antibiotic stewardship. Omi pointed out that for bacteria for which we have less than 30 isolates, the data is less reliable and trends over time (i.e. looking back at old antibiograms) may be helpful in choosing the empiric treatment. You can see on the antibiogram below, the numbers in red reflect the number of isolates from 2023 of that particular bacteria. Reach out to the pharmacist to help you with this. The "30 isolate rule" is a National standard so applies to any antibiogram

Gram Negative Organisms at SSRRH

trends over time for Morganella at SSRRH

Last year, at SSRRH 64% of Gram Negative Organisms were E Coli. Other more commonly isolated organisms include Klebsiella, Pseudomonas, Proteus and Enterobacter.

For general medical patients, >85% susceptibility is considered adequate for empiric antibiotics.

For ICU patients, the higher the better, >90% susceptibility is preferred.

Empiric UTI Treatment

In 2023, SSRRH changed to using Cefoxitin, a second generation cephalosporin, as our first line for empiric parenteral UTI treatment.

Of note, our current rates of susceptibility of E Coli to ciprofloxacin (80%), levofloxacin (77%) and Bactrim (79%) mean that we should NOT be using them for empiric treatment for UTI.

Omi reminded us of a few common clinical circumstances:

• Despite common practice, ceftriaxone does not concentrate well in the urine as cefoxitin. Ceftriaxone should not be first line for UTI treatment
• Once culture results return, use the specific data to drive antibiotic treatment moving forward
• If a patient has had a recent history-- meaning in the last 120 days) of infection at the same site, use that information (and NOT the antibiogram) to drive your empiric antibiotic choice
• ESBL is a form of resistance that presents in gram negative bacteria. 
• The CTX-M gene (aka Ceftriaxone resistance) is a surrogate marker for ESBL 
• Sutter labs will not specifically report out an ESBL organism, so LOOK for ceftriaxone resistance as a surrogate marker for ESBL organisms
• If you suspect an ESBL organism, do NOT use Zosyn, any cephalosporin for empiric treatment. Your best choice is a carbapenem

• For pseudomonas aeruginosa, the only oral abx for this organism locally is ciprofloxacin, and based on 2023 antibiogram, it is currently only 83% sensitive
• do NOT use levofloxacin (77% sensitive)

Empiric Staph Aureus 

• MRSA resistance to clindamycin has been consistently high since 2017 (around 59%)
• do NOT use clindamycin for MRSA coverage
• Resistance to TMP-SMX is increasing in Santa Rosa (>16% resistance rate)
• Doxycycline sensitivity (currently 95%) is significantly higher than tetracycline (68%).
• Tetracycline is NOT a good surrogate marker for doxy against MRSA. Therefore, susceptibilities should be reported separately.
• Doxycycline is a good local choice for empiric MRSA coverage

Empiric Group B Strep (GBS)

• Local GBS is resistant to clindamycin 50% of the time, GAS is resistant 25% of the time
• Clindamycin should never be used to empirically cover GBS in a pregnant woman without sensitivities 
• Unless sensitivity is known, linezolid is preferred over clindamycin to inhibit toxin production (usually just 3 days duration)

Restricted Antibiotics

At SSRRH, certain antibiotics are restricted to ID approval with the intention of preventing misuse/overuse and preserving susceptibility over time. This technique has proven successful in limiting our local resistance. The restricted antibiotics include:

Barriers to Fertility Care (Orozco-Llamas, 9/18/2024)

Many thanks to Dr. Orozco-Llamas for an excellent, thought-provoking presentation this week on Barriers to Fertility Care. A recording of her presentation is available HERE.

My notes:

2020 American Society for Reproductive Medicine definition for infertility:

• Inability to achieve a successful pregnancy based on a patient’s medical, sexual, and reproductive history, age, physical findings, diagnostic testing or any combination of those factors.

• Need for medical intervention to achieve a successful pregnancy either as an individual or with a partner

In patients having regular, unprotected vaginal-penile intercourse, evaluation should be initiated at 

• 12 months when the female is under 35 years of age
• 6 months when female is 35 - 40 years
• Immediate evaluation may be warranted in female >40 years

Infertility affects 15% of heterosexual couples in the US

Male factor accounts for 40-50%

Female factor accounts for 35-50%

Unexplained fertility accounts for ~30%

This talk did not cover the usual fertility evaluation, but a typical plan for infertility includes diagnostic services (serum lab tests, semen analysis, imaging and diagnostic procedures, e.g. laparoscopy or hysteroscopy) and treatment services, including medications (clomiphene/letrozole), surgery (laparoscopy or hysteroscopy), intrauterine inseminations (IUI) and in vitro fertilization (IVF)

Each of these components has an associated cost:

For patients who need fertility specialty care, costs are generally self pay. At our local fertility clinic-- Advanced Fertility Associates, Inc, here are some current out of pocket costs:

• Consult $280 

• US done in-house $275  (even if done already at outside facility)

• Blood work $350 (often needs repeating)

• IUI $400 per cycle

• IVF $10,000-$15,000 per cycle

It is important to note that fertility treatments do not every guarantee a successful pregnancy and many of these costs need to be multiplied to achieve success. If you look at the graph below from KFF, you can see that whereas a single cycle of IUI may cost about $3500 dollars, the average cost per successful pregnancy is over $10,000 dollars. 

Ovulation stimulating medication is relatively low-cost for our Medi-Cal and uninsured patients (~$18 for a course of clomiphene and/or letrozole), but there is currently no in clinic IUI offered at our community health centers. Patients can be counseled on doing home insemination, which has a lower success rate.

We know that IVF has been in the national political conversations lately. It is important to note that there is wide variability in states regarding private insurance mandates around fertility care. 

As of June 2024, 23 states have mandates requiring insurance companies to include some coverage for infertility diagnosis and treatment. Of these, 15 states specifically require coverage for IVF. Most require a clinical diagnosis of infertility, often requiring all people seeking coverage, including single people and people in same sex partnerships, to demonstrate clinical infertility (sometimes requiring a rounds of IUI before covering IVF).

Where policies cover IVF, coverage is limited by either a dollar limit or a maximum number of IVF cycles.  Several of the states that mandate insurance coverage of infertility treatment do not require religious organizations, small businesses, or employers who self-insure to offer coverage. Several states require that the patient be married. Many states place an age limit on infertility treatment.

No state Medicaid (in California, MediCal) currently covers IUI or IVF.

***

All this being said, patients of color and patients with low SES have higher rates of infertility! In fact

• All non-white racial and ethnic groups (black, other race, and Hispanic) are significantly more likely to experience infertility than whites.

• Both high school dropouts and high school graduates are significantly more likely to experience infertility than four-year college graduates. 

• Women who are not white and women who are of lower SES are significantly less likely to report ever having received infertility treatment.

This is an equity issue. It shouldn't be surprising that women seeking fertility treatments tend to be older, white, of higher income and privately insured. 

Also of note, there is evidence that women who work with pesticides have higher rates of infertility. See image below for details on two studies that are highlighted. This is particularly relevant to many of our local SoCo patients who work in vineyards and local farming industry. 

What can primary care docs working in the safety net do with patients who need fertility services?

• Talk to your  patients about fertility!

• Refer to WHPC or GYN clinic at Vista SRCH

• Education on infertility and ovulation cycle

• Mental health resources

• Diet and lifestyle modifications

• Guidance on when to refer and providing financial information

References:

• Bill Status - SB-729 Health Care Coverage: Treatment for Infertility and Fertility Services. leginfo.legislature.ca.gov/faces/billStatusClient.xhtml?bill_id=202320240SB729.
• Figà-Talamanca, Irene. “Occupational risk factors and reproductive health of women.” Occupational medicine (Oxford, England) vol. 56,8 (2006): 521-31. doi:10.1093/occmed/kql114
• Fuortes, L et al. “Association between female infertility and agricultural work history.” American journal of industrial medicine vol. 31,4 (1997): 445-51.
• Gaskins, Audrey J, and Jorge E Chavarro. “Diet and fertility: a review.” American journal of obstetrics and gynecology vol. 218,4 (2018): 379-389. doi:10.1016/j.ajog.2017.08.010
• “Infertility: An Overview Patient Education Booklet.” Infertility: An Overview Patient Education Booklet | ReproductiveFacts.Org, American Society for Reproductive Medicine, www.reproductivefacts.org/news-and-publications/fact-sheets-and-infographics/infertility-an-overview-booklet/.
• Infertility Workup for the Women’s Health Specialist: ACOG Committee Opinion, Number 781. Obstetrics & Gynecology 133(6):p e377-e384, June 2019. | DOI: 10.1097/AOG.0000000000003271
• Katz, Patricia et al. “Costs of infertility treatment: results from an 18-month prospective cohort study.” Fertility and sterility vol. 95,3 (2011): 915-21.
• Mays, Mackenzie. “A Bay Area Cancer Patient Froze Her Eggs in Hopes of Having Children. She Can’t Afford to Finish IVF - Los Angeles Times.” Los Angeles Times, 9 Apr. 2024, www.latimes.com/california/story/2024-03-31/ivf-isnt-covered-by-insurance-in-california-hopeful-parents-are-struggling-to-afford-fertility-care.
• Phillips, Kiwita, et al. “Infertility: Evaluation and Management.” AAFP, 15 June 2023, www.aafp.org/pubs/afp/issues/2023/0600/infertility.html.
• Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org. “Definitions of infertility and recurrent pregnancy loss: a committee opinion.” Fertility and sterility vol. 113,3 (2020): 533-535. doi:10.1016/j.fertnstert.2019.11.025
• Weigel, Gabriela, et al. “Coverage and Use of Fertility Services in the U.S. | KFF.” KFF, 15 Sept. 2020, www.kff.org/womens-health-policy/issue-brief/coverage-and-use-of-fertility-services-in-the-u-s.

CKD transition to Hemodialysis (Cheung, 9/11/2024)

 Many thanks to Dr. Eric Cheung, nephrologist, for a great talk on transitioning patients with CKD to Hemodialysis. 

A recording of his presentation is available HERE. 

My notes:

Dr. Cheung began with the global trends of dialysis. While center-based hemodialysis (HD) is much more common in the US (~90% of US pts), home peritoneal dialysis (PD) is much more common in developing countries (it’s cheaper and requires less infrastructure). Interestingly PD rates are also quite high in Hong Kong (80%) where ALL patients are mandated to start dialysis on PD. 

In general the highest rates of dialysis are in the wealthiest countries. 

 

In the US, there are 468,000 patients on dialysis, and 193,000 with a functional transplant.

One area we need to improve in is telling our patients they have CKD.  

• Of patients who have CKD 1-3 (who are thus asymptomatic), less than 10% know they have CKD
• For patients who are CKD stage 4, only 45% know they have CKD. Yikes!

 

There are several types of transition from advanced CKD:

• Advanced CKD -> dialysis
• Advanced CKD -> pre-emptive transplantation
• Changing dialysis modalities (HD>> PD, PD>> HD)
• Failed transplant -> dialysis
• Dialysis -> transplant

And don’t forget that no initiation of dialysis is an option- just conservative management

 

Categorizing patient risk for progression from CKD to HD:

• High Risk Patients: any patient with diabetes (especially those with proteinuria), uncontrolled HTN, CHF, cirrhosis, >60 years old, and Polycystic kidney disease.
• Lower Risk Patients: AKI with recovery (i.e. Sepsis, cardiac arrest, dehydration, obstructive uropathy), ironically Polycystic kidney disease (really based on family history—if hx of PKD on HD high risk for HD, if PKD but no progression, unlikely to progress)

There is an online calculator to help! https://kidneyfailurerisk.com

 

Does it help to start dialysis early (GFR 10-14) vs late (GFR 5-7)?

• The IDEAL study for ASYMPTOMATIC patients with CKD shows us that there is NO difference in mortality. So…
• if the eGFR is >15 or is 5-15 without symptoms -> monitor (of course with the help of your friendly neighborhood nephrologist
• if the eGFR is 5-15 with symptoms or <5 -> start dialysis
• 
  

Initiation of dialysis is risky!  Especially the first several months— there is a 7-10x increase in death (even over all dialysis patients who already have a high mortality)! Cardiovascular and infectious causes are major causes of increased mortality. Indications to initiate dialysis include:

·         Absolute indications: uremic encephalopathy, uremic pericarditis/pleuritis

·         Common indications: declining  nutrition/appetite, fatigue/malaise, mild cognitive impairment

Ideally, initiation starts gradually with advanced planning including setting expectations and getting long-term access coordinated (see below).

However, some patients need to start HD in the hospital – if no other option, poorly controlled HTN or hypotension, active angina, hx of seizures, or lack of social support.

 

Hemodialysis Access:

·         AV fistula is preferred and often lasts the longest and is basically a direct connection of the artery and vein in the forearm. Greatest risk of clot in the first month but thereafter clots are uncommon. Can last decades.

·         AV graft needed sometimes in vasculopaths and connect the artery and vein, but tends to clot when no longer in use.

·         Central venous catheter/tunneled cath: definitely least preferred but often used in transition. It is inserted into the internal jugular (NEVER the subclavian due to risk of stenosis), double lumen 14-16 french.

Tips from your friendly nephrologist for primary care providers:

 Medications to avoid/adjust:

o   DM: ask CKD progresses, pts generally need less insulin needed because it hangs around longer; ALWAYS stop metformin when GFR <30 to avoid lactic acidosis; and d/c thiazolidinediones

o   HTN: as CKD progresses, stop ACE/ARBs (but after they start on HD they are great HTN meds)

o   Seizure/Pain meds: avoid gabapentin and baclofen which have toxic metabolites in CKD/ESRD

o   Antibiotics: Bactrim/Septra – don’t use in CKD patients since the SMX component can cause hyperkalemia; Cefepime can accumulate (care with this!)

 Preserve the Veins in your CKD patients long BEFORE they may need dialysis!

• Avoid subclavian lines
• Avoid PICC lines and midlines as much as possible
• For phlebotomy, use dorsal veins of the dominant hand instead of AC fossa

And last but not least. . .Dr. Cheung’s personally preferred form of dialysis? (and hopefully he never needs it!)….HD at HOME!  (yes, this is actually an option). Rare but has lower mortality and complications than HD at centers

Neurodiversity in Medical Education (Biradar, 9/4/2024)

Deep gratitude this week to Dr. Sony Biradar for a thought-provoking Grand Rounds presentation on Neurodiversity in Medical Education. It was one of those presentations that sticks with you all day, makes you wonder if maybe you've been thinking about things incorrectly for a long time. I recommend watching the recording if you or someone you love identifies as neurodivergent OR if you work with or supervise someone who does.

A link to the recording will be available HERE.

Here are some key take homes:

• Neurotypical describes someone whose cognition is aligned with societal norms, i.e. whose brain functions are considered usual or expected by society.
• Neurodivergence describes someone whose cognition and processing are different than "the societal norm".
• Some neurodivergent people have an associated diagnosis (e.g. ADHD, autism), but not all.
• 15-20% of the population is neurodivergent 
• Neurodivergent people suffer high rates of unemployment, have disproportionate rates of anxiety, depression and risk of suicide

Dr. Biradar spent a fair amount of time talking about the idea of disability as a social construct -- first, that neurodivergence has long existed in society and may even have some developmental benefits that has ensured its persistence. In the medical model of disability (one which we are all a part of), impairments that affect one's quality of life need to be "fixed". In contrast, in the social model of disability, conditions are themselves not a disability, it is societal structures that make them disabling. 

The prevalence of neurodiversity in medical training has not been well-studied, nor has the experience of students and trainees. Dr. Biradar posits that certain adaptive behaviors/challenges may be heightened in neurodivergent trainees:

• masking: trying to hide one's neurodivergence may lead to increased exhaustion, higher rates of burnout, and even increased suicidality
• hidden curriculum (socialization that happens for trainees when what they see differs from what is said/what they are taught)
• imposter syndrome: may be increased for neurodivergent trainees
• double empathy: a type of stereotype threat. . .
• otherness: when trainees feel different from the norm, this may impact their ability to learn and perform

Dr. Biradar talked about how the process of moving through residency training-- acquiring knowledge and skills from attendings -- may simply be more challenging for neurodivergent trainees simply because the way they work/think is, by definition, different from the "medical norm". 

Residency training is known to be intense, overwhelming, and stressful. The inputs are numerous.

Experiencing this level of stress as a neurodivergent learner may be particularly overwhelming. Don't forget intersectionality,  Dr. Biradar cautions, for we know that other identities (namely BIPOC learners already experience these 

What can we do? How do we support neurodivergent learners? 

Start with being strength-based, says Dr. Biradar. Look for ways to help learners demonstrate their strengths, do not just focus on their deficits. Also, consider the theory of multiple intelligences-- different ways that learners learn and acquire new information (oral, visual, audio, reading, etc). Offer multiple options.  Promote psychological safety in your learning environment, as well as mentorship. Also encourage and promote increased neurodiversity in leadership and encourage community. 

Finally, consider the concept of compassionate pedagogy, asks us to be critical of institutional and cultural practices in medical training.  Compassionate pedagogy is a collection of teaching practices designed to foster human connection, communication, and wellbeing. The approach revolves around listening to students’ lived experiences and offering flexibility to accommodate their struggles. If we want our students to learn well, we need to honor the often imperfect way they show up. 

Dr. Biradar closed her presentation with the comic below, which captures some of the challenges of neurodivergent learners -- and the potential benefit of medication treatment for some conditions (in this case ADHD). 

References:

AoME Insights Embracing Neurodiversity in our Healthcare Educators 29 March 2023. (2023). Academy of Medical Educators.

https://www.youtube.com/watch?v=Ugx2WjkKvSI

Duong D, Vogel L. Untapped potential: embracing neurodiversity in medicine. CMAJ. 2022 Jul 18;194(27):E951-E952. doi:

10.1503/cmaj.1096006. PMID: 35851534; PMCID: PMC9299741.

Fung, L.K. & Doyle, N. (2021). Neurodiversity. The new diversity. In: Neurodiversity. From Phenomenology to Neurobiology and

Enhancing Technologies.

Goldberg H. Unraveling Neurodiversity: Insights from Neuroscientific Perspectives. Encyclopedia. 2023; 3(3):972-980.

https://doi.org/10.3390/encyclopedia3030070

Hamilton LG, Petty S. Compassionate pedagogy for neurodiversity in higher education: A conceptual analysis. Front Psychol. 2023 Feb

16;14:1093290. doi: 10.3389/fpsyg.2023.1093290. Erratum in: Front Psychol. 2024 Feb 20;14:1345256. doi:

10.3389/fpsyg.2023.1345256. PMID: 36874864; PMCID: PMC9978378.

Robinson D. Neurodiversity in medical education: How can we improve postgraduate learning for neurodiverse doctors? Med Teach.

2022 May;44(5):564-566. doi: 10.1080/0142159X.2022.2039383. Epub 2022 Mar 2. PMID: 35236237.

Shaw SCK, Fossi A, Carravallah LA, Rabenstein K, Ross W, Doherty M. The experiences of autistic doctors: a cross-sectional study.

Front Psychiatry. 2023 Jul 18;14:1160994. doi: 10.3389/fpsyt.2023.1160994. PMID: 37533891; PMCID: PMC10393275.

Syharat CM, Hain A, Zaghi AE, Gabriel R, Berdanier CGP. Experiences of neurodivergent students in graduate STEM programs. Front

Psychol. 2023 Jun 15;14:1149068. doi: 10.3389/fpsyg.2023.1149068. PMID: 37397290; PMCID: PMC10311419.

Taylor G. Editorial: Embracing neurodiversity in medicine. Aust J Gen Pract. 2021 Mar;50(3):101. doi: 10.31128/AJGP-03-21-1234e.

PMID: 33634273.

Perinatal Mood Disorders (Zechowy, 8/28/2024)

Many thanks to Dr. Jill Zechowy for an excellent presentation this week on Perinatal Mood Disorders. A link to the recording is available HERE. 

My notes:

• PPD: perinatal/post partum depression
• PPA: perinatal/post partum anxiety
• PMADs: perinatal mood disorders (including depression, bipolar, anxiety including panic, OCD, GAD)

PPD is persistent low mood lasting >2 weeks, occurring in pregnancy or in first year postpartum, dx'd the same as other forms of depression with the SIGECAPS pneumonic:

• Sleep
• Reduced Interest
• Guilt
• Low Energy
• Impaired Concentration (may be criteria for extending disability)
• Appetite (crave carbs, have low appetite)
• Psychomotor agitation or slowing
• Suicidality

In the first YEAR of life, maternal mental health diagnoses are the number 1 cause of maternal mortality (death from suicidality and/or drug overdose)

PPD differs from major depression in a few ways: more anxiety, changed sleep/lifestyle, parenting responsibilities

Costs for moms/women: PPD affects 1/7 women, PMADs in 1/5 women, 1/10 partners/adoptive parents (roughly 1 million people/year). Depression impairs women's ability to bond with baby, delays/impairs attachment. Depressed moms are less responsive to their babies -- children born to women with untreated PPD are more likely to have externalized behaviors (e.g. conduct issues, fights in school, shouting, hitting, aggressive behaviors). PMADs major cause of divorce, suicide.

Costs to infant: if a person with a uterus is pregnant with depression, more likely to have pre-term birth, SGA, impaired brain growth, developmental delay, behavioral disorders, attachment disorders. Untreated PPD is an ACE for the child.

Who is at risk? People with prior history of depression/anxiety is at increased risk, family history depression/anxiety (even  in a male relative) increases risk of PPD. Trouble sleeping in pregnancy has the strongest correlation with PPD in perinatal time. 

PPD is caused, in part, by hormone changes (e.g. allopregnanolone levels plummet at birth, women with a genetic issue with pregnanolone receptors have severe PPD). But hormones are only part of the explanation. There are other biological issues. Right now, our awareness of mental health of children is so acute that it is a particularly difficult time to mother/parent. The demands of parenting are also an extreme stress.

Screening

All pregnant people should be screened for PPD, positive Edinburgh screening is 9-12 (out of total 30). ACOG recommends in first trimester, again at "later trimester" and every postpartum visit. AAP recommends "mothers be screened for PPD at 1, 2, 4 and 6 month visits". 

• Assess for suicidality: pay particular attention to the suicide question on your screening tool.
• Ask how women are sleeping.
• Screen for bipolar disorder: history of bipolar disorder, family with bpd, ever a time they were agitated/impulsive/didn't sleep/more sexual
• bipolar disorder most often diagnosed postpartum
• Look for evidence of psychosis

Intrusive thoughts vs. Postpartum psychosis

Intrusive thoughts are common in perinatal period (common in PPA, OCD flare). Intrusive thoughts are scary, harsh images of harm coming to the baby (e.g. tripping on baby, imagining pot of hot water burning the baby). These intrusive thoughts make women scared of holding the baby. These get better with time away from baby, more sleep, more support, or OCD/anxiety is treated. They are NOT at risk of harming their baby because the idea is abhorrent.

In psychosis, it is more ego-syntonic. It feels okay, comfortable. People hear voices to kill their baby. This is VERY different. Women with psychosis have very high risk of infanticide (1/1000 risk of killing baby). They need urgent assessment and should not be left alone with their baby. Need ER assist. There is a mother-baby unit in Stanford. 

Principles of treatment

Therapy, medications are both first line. Medication may be more accessible in resource-poor settings.

Also, try not to allow breastfeeding to impair sleep: 5 hours in a row is better than 8 hours with three interruptions due to 3 REM cycles in a row, which is more replenishing for our brain biochemistry.

Don't be shaming when talking about breastfeeding. If a bottle of formula (or pumped milk) allows mom to get 5 hours of sleep, no shame and no blame. Can use power pumping, which is better than pumping in the middle of the night (don't set your alarm q3 hours to pump in the middle of the night).

Medication prescribing: weigh risks of treating vs. risk of untreated depression.

Don't change medication just because a woman is pregnant. 

Don't treat someone halfway (e.g. the lowest dose, but not effective dose, increase sertraline from 25 mg (too low) to more effective/therapeutic dose). When you do this, you are exposing infant to both the medication AND the depression.

Sertraline (Zoloft) has the most safety data, but that doesn't mean it's the safest medication. There isn't enough data to know which SSRI is safer. Sertraline does work for a wide range of diagnoses, so if a woman isn't on medication, sertraline is a good first start. BUT if a person has tried multiple anti-depressants, it's okay to continue that medication; don't switch to sertraline, especially if it didn't work for them in the past.

Perinatal psychiatrists use Reprotox.net (has every study on any medication in pregnancy) or MothertoBaby.org (patient handouts Eng/Spanish)

5 Risks of SSRI:

• poor neonatal adaptation (akin to SSRI withdrawal), occasionally NICU for monitoring and blood sugar
• pulmonary hypertension of newborn: very low risk
• cardiac defects ?some studies show yes, others no (cardiac side effects documented in paroxetine, fluoxetine (rx'd often for PMDD)
• bipolar disorder: do not want to precipitate mania, consider quetiapine QHS for someone who have postpartum bipolar disorder. Get psychiatrist help
• suicidality (always recheck 2 weeks after starting SSRI). Agitation can happen without warning, can be result of agitation that an SSRI can cause, unknown element of BPD. National Suicide Hotline 9-8-8. If they have thoughts of hurting themselves, should stop the med and let you know. 

For Insomnia/Post Partum Anxiety: can use very very very low doses of quetiapine (1/4-1//8 of a 25mg tablet of quetiapine): undetectable in breastmilk. May be safer than sleeping meds (less likely to roll over baby). Consider as adjunct for anxious patients who do not meet criteria for mania but for whom you are worried about starting sertraline. 

The newest treatment option for PPD is Zuranolone: synthetic analog of allopregnanolone. Works very quickly (within 3 days). Only 2 week course (14 pills), Can be done on top of SSRI, anti-psychotic, lithium. Causes profound sedation (no driving). No safety information in breastmilk. Very costly: $1000+/pill, $15,000 for a course. 

Preventing PPD

With specific techniques, up to 50% of PPD can be prevented. Lots of studies that we can prevent a good percentage of PPD: self care, support, sleep. Needs to be included in prenatal classes. We need policy change (paid maternity leave in the US!). Need to address partner treatment (male/female).

Oxygen Delivery and BiPAP (Manjuck, 8/14/2024)

Many thanks to Dr. Janice Manjuck, our SSRRH ICU Director, for an excellent Grand Rounds  this week on Oxygen Delivery and BiPAP for hospitalized patients. Dr. Manjuck gave us a nitty gritty review of when/how/why we might select one of many oxygen delivery devices. She combines humor, basic science, and evidence in just the right blend to bring us clinically relevant learning. We are so grateful!

A recording of her presentation is HERE. Feel free to check it out.

My notes:

First, off, when should we be using oxygen?

• if patient is acutely ill, oxygen is not indicated unless saturation is <96% (this excludes sickle cell crisis, CO poisoning, profound anemia (Hb <3) and pneumothorax
• in ACS/CAD aim for 93% saturation

Hypoxemia is a theoretical concern.

Pulse oximetry is not always reliable. SQ1 of 1 on the monitor tells us if the signal is reliable We should be suspicious about pulse oximetry -- it is not reliable in cases of poor perfusion, nail polish/artificial nails (think Olympic runners), tremor/movement disorder/seizure, anemia and CO poisoning (e.g. HB<5, bilirubin>30), bright lights (can falsely lower readings).

Of note, patients of color are MUCH less likely to have reliable reading from a pulse oximeter.

In a 2022 NEJM study of patients comparing ABG results to pulse oximeter readings, 11% of black patients had falsely elevated pulse ox readings (compared to 3% of white patients). This means a normal pulse oximeter reading may be falsely reassuring in BIPOC patients. 

ABG vs. VBG: For patients NOT in shock, a VBG is a relatively good alternative to an ABG,  particularly if you are getting the VBG to trend PCO2 in hypercapnic patients. VBGs are easier to get and less painful for patients. However, please note, if a patient is in shock, an ABG may be needed. Do not be offended if the intensivist asks for an ABG for an unstable floor patient!

Okay, when patients need oxygen, what kind of oxygen should I give them? It is important to take into account their clinical status, their comorbidities, and why they need oxygen. Low flow systems, which can deliver 0-15LPM of oxygen, are good for patients with a stable respiratory rate and pattern. High flow systems -- which can deliver 50-60 LPM-- may be better for patients who are more tachypneic. 

Dr. Manjuck reviewed the concepts of anatomical dead space and entrainment

• Anatomical dead space  is the internal volumes of the upper airways, in which no gas exchange takes place -- on average about 150 ML in a 70 kg person. Air is warmed, filtered and humidified in this space, but no gas exchange occurs. So it is essentially "wasted space". 
• Entrainment is when room air mixes with oxygen due to a negative pressure gradient. In other words, it is the air that leaks around the oxygen delivery device. This is more common in nasal cannula<<face mask<<HFNC.

Which oxygen device is indicated? Depending on this oxygen needs of the patient, these two concepts may be important in which oxygen delivery device you choose. Other questions include: what interface is more desirable (e.g. nasal cannula vs. face mask)? how precise does the FiO2 need to be titrated? Does the air need to be humidified? Are other therapies (e.g. bronchodilator) needed? Low flow delivery tends to be more comfortable.

Low flow oxygen delivery systems include nasal cannula (NC), simple face mask, non-rebreather face mask, and venturi face masks. They can  deliver 0-15 LPM of oxygen. 

• Nasal cannula coming from wall is always delivering 100% oxygen, each 1L/min is equivalent to 3-4% FiO2, remembering that room air contains approximately 21% oxygen, SO
• 1 LPM=24% oxygen
• 2LPM=28% oxygen
• 3LPM=32% oxygen
• 4LPM=36% oxygen
• 5LPM=40% oxygen
• And so on. . .This means that 10 LPM on a nasal cannula gets you about 60% FiO2. See chart .
• A (simple) low flow mask can delivers upwards of 60-70% FiO2 IF the patient is breathing normally (essentially maxed out at 15LPM)
• A non-rebreather mask ALSO gives about 15LPM max of oxygen, which is ~60-70%. It does not flood the face, but rather floods the bag, which is a means to effectively deliver high levels of oxygen anywhere in the hospital. It can deliver 75-90% FiO2, but100% non-rebreather should be considered a fast track to something else (i.e. BiPAP, HFNC or intubation)
  
  

High flow systems include HFNC, CPAP, BiPAP, and mechanical ventilators; these are all positive-pressure systems and can deliver 15-60 LPM. This level of oxygen delievery is indicated in profound hypoxemia, hypercapnia AND/OR both. 

Positive pressure systems can recruit alveoli, assist mechanical work of breathing, may ensure better oxygen delivery and increase functional residual capacity. Disadvantages include being confining/claustrophobia-inducing, may increase the need for sedation, increase risk of infection, increase in aerophagia, and they may reduce cardiac output (especially if patient is dry). 

HFNC, which delivers 50-60 LPM, must ALWAYS be humidified and warmed. It offers "a little PEEP" for patients who need it. Good for elevated respiratory rate.  Continuous high flow oxygen literally washes out the upper airways, leaving a reservoir of oxygen in the upper airway (pharynx) available for ongoing oxygen exchange. It also avoids rebreathing CO2, thereby decreasing anatomical dead space. 

EPAP=CPAP=PEEP

Home CPAP has variable oxygen delivery, is not titratable, and not always humidified. Do NOT use home CPAP if patient hospitalized for respiratory reason. Hospital CPAP, on the other hand, is more titratable in terms of PEEP. 

The worse the hypercapnia, the better to use BiPAP. Think of BiPAP as a non-invasive ventilator. It has different interfaces, can be humidified, you can titrate the oxygen more precisely, and you get feedback on its efficacy. 

Tradition to Transition: Dietary Shifts in Immigrant Patients (Rayas, 8/7/2024)

Muchas gracias to Dr. Lourdes "Lulu" Rayas for a wonderful presentation this week on food customs and Habits in our Mexican immigrant patient population. She titled the presentation, From Traditional to Transitional: Dietary Shifts with Immigration.  

A recording of her wonderful (and tasty) presentation is available HERE. 

***

My notes:

16% of our population in Sonoma County is foreign born.

Chronic disease is more prevalent  in the Latinx population. In fact, compared to non-Hispanic whites,

• Hispanic adults 70% more likely be diagnosed with DM2
• Hispanics are 1.3x more likely to die from diabetes 
• Hispanics have 2x risk of being hospitalized with ESRD

Of note, the immigrant paradox is a statistical pattern that shows first-generation immigrants may have better health outcomes than native-born people of the same age, race, and gender, even if they have lower socioeconomic status. This pattern has been observed for cardiovascular disease, mental health, and mortality. However, recent research suggests that immigrants may experience a decline in cardiovascular health over time. 

Some of this paradox may be explained by dietary acculturation-- the notion that, over time, immigrants gradually abandon eating habits from their native countries, ultimately increasing fats, sugary beverages, and decreasing fruits and vegetables. 

Children of immigrants have also been noted to have less physical activity (than native born children) and less healthy diets. 

In a study of Latinx immigrants, people were asked to share the pros and cons of their eating habits and food access in their country of origin as compared to the USA. You can see these lists in the images below. I was most struck by the notion that many immigrants literally do not have the time to cook like they did when they lived in their country of origin -- this is likely due to long work hours and less flexible home schedules. Also note, that people report eating more legumes (and less meat) in their country of origin. 

So what can we do as primary care providers? 

Dr. Lulu encouraged us to adhere to three principles: 1) have a culturally competent approach to nutrition 2) help patients find a community that shares valued and traditions, and 3) connect patients to food access resources. 

Culturally competent nutrition

Traditional Mexican cooking, Dr. Rayas, pointed out, contains tons of fresh fruits and vegetables and very little processed foods. We can encourage our patients to carry forward traditional family  menus and discourage processed foods. Commonly used foods used in Mexican cooking have well-documented health benefits:

• tomato (jitomate) has evidence that it lowers lipids, decreases blood pressure and general inflammation
• peppers (chiles) help with glucose metabolism 
• avocado (aguacate) decreases CVD, cancer, and works on the GLP system
• corn (elote) has been shown to be anti-inflammatory, anti-angiogenesis properties, and anti-carciongenic. (And, btw, corn is the foundation of the Mexican diet). 
• cactus (nopales) also has anti-inflammatory properties, hypoglycemic (one study showed 85gm of nopales daily demonstrated a 20% reduction in glucose levels), and anti-microbial. 
• hibiscus (jamaica) can decrease blood pressure (in one study from 134 to 112 SBP it drunk BID x 1 month)
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Help patients find community

Many of our immigrants patients are isolated and need help accessing community services and opportunities. Don't forget about some of our amazing community resources, including:

• Bayer Farms: a community garden space, sponsored by Land Paths, they offer garden space, herbal medicine classes, and a great park/playground
• The Botanical Bus: featuring bilingual health promotoras bringing a mobile herb clinic all around Sonoma County
• Campeones de Salud, a 6 week program run by SRCH for families to improve healthy eating and exercise (SRCH referral SA260 Dutton)
• Center for Well-Being, which offers nutrition classes in English and Spanish (SRCH providers can refer via EpiC)

Connecting patients with food access resources, including:

• WIC, a food supplementation program for pregnant women, post partum and breastfeeding, and children up to age 5.  
• Ceres Community Project, free medically tailored meals for patients with chronic illness, including heart failure, cancer, and diabetes. 
• Redwood Empire Food Bank, which comes to Vista Clinic every Monday from 11am-12pm.